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Journal Article

Azine Activation via Silylium Catalysis

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Obradors,  Carla
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List,  Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Obradors, C., & List, B. (2021). Azine Activation via Silylium Catalysis. Journal of the American Chemical Society, 143(18), 6817-6822. doi:10.1021/jacs.1c03257.


Cite as: http://hdl.handle.net/21.11116/0000-0008-EEA8-F
Abstract
Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.