Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 
9.4T

Tuzzi, E; Pohmann, R; Loktyushin, A; Laske, C; Scheffler, K; Hagberg, GE

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Meeting Abstract

Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T

MPS-Authors

/persons/resource/persons214563

Tuzzi, E
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84145

Pohmann, R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84372

Loktyushin, A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83952

Hagberg, GE
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://www.ismrm.org/21/program-files/CES-05A.htm
(Abstract)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Tuzzi, E., Pohmann, R., Loktyushin, A., Laske, C., Scheffler, K., & Hagberg, G. (2021). Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T. In 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

Cite as: https://hdl.handle.net/21.11116/0000-0008-EF18-1

Abstract

Beta-amyloid (Aβ) plaques are characteristic of Alzheimer’s Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p<0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p<0.05) diamagnetic effects in AD compared to HC.