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Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T

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Tuzzi,  E
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Loktyushin,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg,  GE
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Tuzzi, E., Pohmann, R., Loktyushin, A., Laske, C., Scheffler, K., & Hagberg, G. (2021). Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T. In 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).


Cite as: http://hdl.handle.net/21.11116/0000-0008-EF18-1
Abstract
Beta-amyloid (Aβ) plaques are characteristic of Alzheimer’s Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p<0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p<0.05) diamagnetic effects in AD compared to HC.