A thalamocortical top-down circuit for associative memory

Pardi, M. Belén; Vogenstahl, Johanna; Dalmay, Tamas; Spanò, Teresa; Pu, De-Lin; Naumann, Laura B; Kretschmer, Friedrich; Sprekeler, Henning; Letzkus, J.J.

doi:10.1126/science.abc2399

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A thalamocortical top-down circuit for associative memory

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Pardi, M. Belén
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Vogenstahl, Johanna
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Dalmay, Tamas
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Donders Centre for Neuroscience, Faculty of Science, Radboud University;

Spanò, Teresa
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Faculty of Biological Sciences, Goethe Universität Frankfurt;

Pu, De-Lin
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Kretschmer, Friedrich
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

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Letzkus, J.J.
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Institute for Physiology I, Faculty of Medicine, University of Freiburg;

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https://pubmed.ncbi.nlm.nih.gov/33184213/
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Citation

Pardi, M. B., Vogenstahl, J., Dalmay, T., Spanò, T., Pu, D.-L., Naumann, L. B., et al. (2020). A thalamocortical top-down circuit for associative memory. Science, 370(6518), 844-848. doi:10.1126/science.abc2399.

Cite as: https://hdl.handle.net/21.11116/0000-0008-F959-C

Abstract

The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are tightly and dynamically controlled by local presynaptic inhibition. Our results not only identify the higher-order thalamus as a highly plastic source of cortical top-down information but also reveal a level of computational flexibility in layer 1 that goes far beyond hard-wired connectivity.