Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

A thalamocortical top-down circuit for associative memory

MPG-Autoren

Pardi,  M. Belén
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Vogenstahl,  Johanna
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Dalmay,  Tamas
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Donders Centre for Neuroscience, Faculty of Science, Radboud University;

Spanò,  Teresa
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Faculty of Biological Sciences, Goethe Universität Frankfurt;

Pu,  De-Lin
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Kretschmer,  Friedrich
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208074

Letzkus,  J.J.
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Institute for Physiology I, Faculty of Medicine, University of Freiburg;

Externe Ressourcen

https://pubmed.ncbi.nlm.nih.gov/33184213/
(beliebiger Volltext)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Pardi, M. B., Vogenstahl, J., Dalmay, T., Spanò, T., Pu, D.-L., Naumann, L. B., et al. (2020). A thalamocortical top-down circuit for associative memory. Science, 370(6518), 844-848. doi:10.1126/science.abc2399.


Zitierlink: https://hdl.handle.net/21.11116/0000-0008-F959-C
Zusammenfassung
The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are tightly and dynamically controlled by local presynaptic inhibition. Our results not only identify the higher-order thalamus as a highly plastic source of cortical top-down information but also reveal a level of computational flexibility in layer 1 that goes far beyond hard-wired connectivity.