A Critical Role for Neocortical Processing of Threat Memory

Dalmay, Tamas; Abs, Elisabeth; Poorthuis, Rogier E.; Hartung, Jan; Pu, De-Lin; Onasch, Sebastian; Lozano, Yave R.; Signoret-Genest, Jérémy; Tovote, Philip; Gjorgjieva, Julijana; Letzkus, Johannes J.

doi:10.1016/j.neuron.2019.09.025

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A Critical Role for Neocortical Processing of Threat Memory

MPS-Authors

Dalmay, Tamas
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Abs, Elisabeth
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208150

Poorthuis, Rogier E.
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Hartung, Jan
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Pu, De-Lin
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

Onasch, Sebastian
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons207974

Gjorgjieva, Julijana
Computation in Neural Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
School of Life Sciences, Technical University of Munich;

/persons/resource/persons208074

Letzkus, Johannes J.
Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

External Resource

https://pubmed.ncbi.nlm.nih.gov/31727549/
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Dalmay, T., Abs, E., Poorthuis, R. E., Hartung, J., Pu, D.-L., Onasch, S., et al. (2019). A Critical Role for Neocortical Processing of Threat Memory. Neuron, 104(6), 1180-1194.e7. doi:10.1016/j.neuron.2019.09.025.

Cite as: https://hdl.handle.net/21.11116/0000-0008-F9A3-7

Abstract

Memory of cues associated with threat is critical for survival and a leading model for elucidating how sensory information is linked to adaptive behavior by learning. Although the brain-wide circuits mediating auditory threat memory have been intensely investigated, it remains unclear whether the auditory cortex is critically involved. Here we use optogenetic activity manipulations in defined cortical areas and output pathways, viral tracing, pathway-specific in vivo 2-photon calcium imaging, and computational analyses of population plasticity to reveal that the auditory cortex is selectively required for conditioning to complex stimuli, whereas the adjacent temporal association cortex controls all forms of auditory threat memory. More temporal areas have a stronger effect on memory and more neurons projecting to the lateral amygdala, which control memory to complex stimuli through a balanced form of population plasticity that selectively supports discrimination of significant sensory stimuli. Thus, neocortical processing plays a critical role in cued threat memory.