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Journal Article

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

MPS-Authors
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Eippert,  Falk
Max Planck Research Group Pain Perception, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Freund,  Patrick
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Leutritz,  Tobias
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf,  Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Cohen_Adad_2021.pdf
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Citation

Cohen-Adad, J., Alonso-Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., et al. (2021). Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific Data, 8: 219. doi:10.1038/s41597-021-00941-8.


Cite as: https://hdl.handle.net/21.11116/0000-0009-17F7-7
Abstract
In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.