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Journal Article

High-precision image-guided proton irradiation of mouse brain sub-volumes.

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Haase,  Robert
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Suckert, T., Müller, J., Beyreuther, E., Azadegan, B., Brüggemann, A., Bütof, R., et al. (2020). High-precision image-guided proton irradiation of mouse brain sub-volumes. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology, 146, 205-212. doi:10.1016/j.radonc.2020.02.023.


Cite as: https://hdl.handle.net/21.11116/0000-0009-0F5B-2
Abstract
Proton radiotherapy offers the potential to reduce normal tissue toxicity. However, clinical safety margins, range uncertainties, and varying relative biological effectiveness (RBE) may result in a critical dose in tumor-surrounding normal tissue. To assess potential adverse effects in preclinical studies, image-guided proton mouse brain irradiation and analysis of DNA damage repair was established.