Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated 
nuclear protein quality control compartments for misfolded proteins.

Mediani, Laura; Guillén-Boixet, Jordina; Alberti, S; Carra, Serena

doi:10.1080/23723556.2019.1652519

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Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins.

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Guillén-Boixet, Jordina
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Mediani, L., Guillén-Boixet, J., Alberti, S., & Carra, S. (2019). Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins. Molecular & cellular oncology, 6(6): 1415624. doi:10.1080/23723556.2019.1652519.

Cite as: https://hdl.handle.net/21.11116/0000-0009-0F65-6

Abstract

We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their efficient clearance. Failure to dispose misfolded proteins converts nucleoli and PML-bodies into a solid state that immobilizes ubiquitin, limiting its recycling for genome integrity maintenance.