Differential H4K16ac levels ensure a balance between quiescence and activation 
in hematopoietic stem cells

Pessoa Rodrigues, Cecilia; Akhtar, Asifa

doi:10.1126/sciadv.abi5987

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells

MPS-Authors

Pessoa Rodrigues, Cecilia
Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons198888

Akhtar, Asifa
Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://advances.sciencemag.org/content/7/32/eabi5987
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

eabi5987.full.pdf
(Publisher version), 5MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Pessoa Rodrigues, C., & Akhtar, A. (2021). Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science Advances, 7(32): eabi5987. doi:10.1126/sciadv.abi5987.

Cite as: https://hdl.handle.net/21.11116/0000-0009-1581-D

Abstract

Hematopoietic stem cells (HSCs) are able to reconstitute the bone marrow while retaining their self-renewal property. Individual HSCs demonstrate heterogeneity in their repopulating capacities. Here, we found that the levels of the histone acetyltransferase MOF (males absent on the first) and its target modification histone H4 lysine 16 acetylation are heterogeneous among HSCs and influence their proliferation capacities. The increased proliferative capacities of MOF-depleted cells are linked to their expression of CD93. The CD93⁺ HSC subpopulation simultaneously shows transcriptional features of quiescent HSCs and functional features of active HSCs. CD93⁺ HSCs were expanded and exhibited an enhanced proliferative advantage in Mof^+/− animals reminiscent of a premalignant state. Accordingly, low MOF and high CD93 levels correlate with poor survival and increased proliferation capacity in leukemia. Collectively, our study indicates H4K16ac as an important determinant for HSC heterogeneity, which is linked to the onset of monocytic disorders.