Discovery of 42 genome-wide significant loci associated with dyslexia

Doust, Catherine; Fontanillas, Pierre; Eising, Else; Gordon, Scott D.; Wang, Zhengjun; Alagöz, Gökberk; Molz, Barbara; 23andMe Research Team,; Quantitative Trait Working Group of the GenLang Consortium,; St Pourcain, Beate; Francks, Clyde; Marioni, Riccardo E.; Zhao, Jingjing; Paracchini, Silvia; Talcott, Joel B.; Monaco, Anthony P.; Stein, John F.; Gruen, Jeffrey R.; Olson, Richard K.; Willcutt, Erik G.; DeFries, John C.; Pennington, Bruce F.; Smith, Shelley D.; Wright, Margaret J.; Martin, Nicholas G.; Auton, Adam; Bates, Timothy C.; Fisher, Simon E.; Luciano, Michelle

doi:10.1038/s41588-022-01192-y

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Discovery of 42 genome-wide significant loci associated with dyslexia

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Eising, Else
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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Alagöz, Gökberk
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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Molz, Barbara
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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St Pourcain, Beate
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society;

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Francks, Clyde
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Imaging Genomics, MPI for Psycholinguistics, Max Planck Society;

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Fisher, Simon E.
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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Citation

Doust, C., Fontanillas, P., Eising, E., Gordon, S. D., Wang, Z., Alagöz, G., et al. (2022). Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics. doi:10.1038/s41588-022-01192-y.

Cite as: https://hdl.handle.net/21.11116/0000-0009-1B5A-5

Abstract

Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.