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Growth-coupled selection of synthetic modules to accelerate cell factory development

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Orsi,  E.
Systems and Synthetic Metabolism, Max Planck Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Lindner,  S. N.
Systems and Synthetic Metabolism, Max Planck Research Groups, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

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Citation

Orsi, E., Claassens, N. J., Nikel, P. I., & Lindner, S. N. (2021). Growth-coupled selection of synthetic modules to accelerate cell factory development. Nature Communications, 12(1): 5295. doi:10.1038/s41467-021-25665-6.


Cite as: http://hdl.handle.net/21.11116/0000-0009-265C-6
Abstract
Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.