日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
一時保存へ追加
  タグ情報を表示リリース履歴を表示詳細要約

公開
学術論文

Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

MPS-Authors
/persons/resource/persons19981

Schroeter,  Matthias L.
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
German Consortium for Frontotemporal Lobar Degeneration (FTLD), Ulm, Germany;

External Resource
There are no locators available
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
フルテキスト (公開)

Song_Beyer_2021.pdf
(出版社版), 2MB

付随資料 (公開)
There is no public supplementary material available
引用

Song, M., Beyer, L., Kaiser, L., Barthel, H., van Eimeren, T., Marek, K., Nitschmann, A., Scheifele, M., Palleis, C., Respondek, G., Kern, M., Biechele, G., Hammes, J., Bischof, G., Barbe, M., Onur, Ö., Jessen, F., Saur, D., Schroeter, M. L., Rumpf, J.-J., Rullmann, M., Schildan, A., Patt, M., Neumaier, B., Barret, O., Madonia, J., Russell, D. S., Stephens, A. W., Mueller, A., Roeber, S., Herms, J., Bötzel, K., Danek, A., Levin, J., Classen, J., Höglinger, G. U., Bartenstein, P., Villemagne, V., Drzezga, A., Seibyl, J., Sabri, O., Boening, G., Ziegler, S., & Brendel, M. (2021). Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET. Journal of Cerebral Blood Flow and Metabolism, 41(11), 2957-2972. doi:10.1177/0271678X211018904.


引用: https://hdl.handle.net/21.11116/0000-0009-2BE6-4
要旨
The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.