English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

On the role of arkypallidal and prototypical neurons for phase transitions in the external pallidum

MPS-Authors
/persons/resource/persons223658

Gast,  Richard
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Methods and Development Group Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons209125

Gong,  Ruxue
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons220625

Schmidt,  Helmut
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19779

Knösche,  Thomas R.
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Gast_Gong_2021.pdf
(Publisher version), 3MB

Gast_pre.pdf
(Preprint), 11MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Gast, R., Gong, R., Schmidt, H., Meijer, H. G., & Knösche, T. R. (2021). On the role of arkypallidal and prototypical neurons for phase transitions in the external pallidum. The Journal of Neuroscience, 41(31), 6673-6683. doi:10.1523/JNEUROSCI.0094-21.2021.


Cite as: https://hdl.handle.net/21.11116/0000-0009-2BE9-1
Abstract
The external pallidum (globus pallidus pars externa [GPe]) plays a central role for basal ganglia functions and dynamics and, consequently, has been included in most computational studies of the basal ganglia. These studies considered the GPe as a homogeneous neural population. However, experimental studies have shown that the GPe contains at least two distinct cell types (prototypical and arkypallidal cells). In this work, we provide in silico insight into how pallidal heterogeneity modulates dynamic regimes inside the GPe and how they affect the GPe response to oscillatory input. We derive a mean-field model of the GPe system from a microscopic spiking neural network of recurrently coupled prototypical and arkypallidal neurons. Using bifurcation analysis, we examine the influence of dopamine-dependent changes of intrapallidal connectivity on the GPe dynamics. We find that increased self-inhibition of prototypical cells can induce oscillations, whereas increased inhibition of prototypical cells by arkypallidal cells leads to the emergence of a bistable regime. Furthermore, we show that oscillatory input to the GPe, arriving from striatum, leads to characteristic patterns of cross-frequency coupling observed at the GPe. Based on these findings, we propose two different hypotheses of how dopamine depletion at the GPe may lead to phase-amplitude coupling between the parkinsonian beta rhythm and a GPe-intrinsic γ rhythm. Finally, we show that these findings generalize to realistic spiking neural networks of sparsely coupled Type I excitable GPe neurons.SIGNIFICANCE STATEMENT Our work provides (1) insight into the theoretical implications of a dichotomous globus pallidus pars externa (GPe) organization, and (2) an exact mean-field model that allows for future investigations of the relationship between GPe spiking activity and local field potential fluctuations. We identify the major phase transitions that the GPe can undergo when subject to static or periodic input and link these phase transitions to the emergence of synchronized oscillations and cross-frequency coupling in the basal ganglia. Because of the close links between our model and experimental findings on the structure and dynamics of prototypical and arkypallidal cells, our results can be used to guide both experimental and computational studies on the role of the GPe for basal ganglia dynamics in health and disease.