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Journal Article

Genetic influences on hub connectivity of the human connectome

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Deco,  Gustavo
Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia;
Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
University Pompeu Fabra, Barcelona, Spain;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Arnatkeviciute, A., Fulcher, B. D., Oldham, S., Tiego, J., Paquola, C., Gerring, Z., et al. (2021). Genetic influences on hub connectivity of the human connectome. Nature Communications, 12(1): 4237. doi:10.1038/s41467-021-24306-2.


Cite as: http://hdl.handle.net/21.11116/0000-0009-41F7-7
Abstract
Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Using transcriptomic atlas data, we show that connected hubs demonstrate tight coupling of transcriptional activity related to metabolic and cytoarchitectonic similarity. Finally, comparing over thirteen generative models of network growth, we show that purely stochastic processes cannot explain the precise wiring patterns of hubs, and that model performance can be improved by incorporating genetic constraints. Our findings indicate that genes play a strong and preferential role in shaping the functionally valuable, metabolically costly connections between connectome hubs.