Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular 
identities of low and high-risk neuroblastoma tumors

Bedoya-Reina, O. C.; Li, W.; Arceo, M.; Plescher, M.; Bullova, P.; Pui, H.; Kaucka, M.; Kharchenko, P.; Martinsson, T.; Holmberg, J.; Adameyko, I.; Deng, Q.; Larsson, C.; Juhlin, C. C.; Kogner, P,; Schlisio, S.

doi:10.1038/s41467-021-24870-7

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Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

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Kaucka, M.
Max Planck Research Group Craniofacial Biology (Kaucka Petersen), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Zitation

Bedoya-Reina, O. C., Li, W., Arceo, M., Plescher, M., Bullova, P., Pui, H., et al. (2021). Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors. Nature Communications, 12: 5309. doi:10.1038/s41467-021-24870-7.

Zitierlink: https://hdl.handle.net/21.11116/0000-0009-49AA-6

Zusammenfassung

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of
the most important prognostic factors, with children less than 1 year old having favorable
outcomes. Here we study single-cell and single-nuclei transcriptomes of neuroblastoma with
different clinical risk groups and stages, including healthy adrenal gland. We compare tumor
cell populations with embryonic mouse sympatho-adrenal derivatives, and post-natal human
adrenal gland. We provide evidence that low and high-risk neuroblastoma have different cell
identities, representing two disease entities. Low-risk neuroblastoma presents a tran-
scriptome that resembles sympatho- and chromaffin cells, whereas malignant cells enriched
in high-risk neuroblastoma resembles a subtype of TRKB+cholinergic progenitor population
identified in human post-natal gland. Analyses of these populations reveal different gene
expression programs for worst and better survival in correlation with age at diagnosis. Our
findings reveal two cellular identities and a composition of human neuroblastoma tumors
reflecting clinical heterogeneity and outcome.