English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Rapid molecular evolution of pain insensitivity in multiple African rodents

MPS-Authors
/persons/resource/persons186289

Barker,  Alison J.
Social Systems and Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine ;

External Resource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Eigenbrod, O., Debus, K. Y., Reznick, J., Bennett, N. C., Sánchez-Carranza, O., Omerbašić, D., et al. (2019). Rapid molecular evolution of pain insensitivity in multiple African rodents. Science, 364(6443), 852-859. doi:10.1126/science.aau0236.


Cite as: http://hdl.handle.net/21.11116/0000-0009-63F1-7
Abstract
Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Nav1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors. These molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant. Our study reveals how evolution can be used as a discovery tool to find molecular mechanisms that shut down pain.