New gene origin and deep taxon phylogenomics: opportunities and challenges

Rödelsperger, Christian; Prabh, Neel; Sommer, Ralf J.

doi:10.1016/j.tig.2019.08.007

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New gene origin and deep taxon phylogenomics: opportunities and challenges

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Rödelsperger, Christian
Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Prabh, Neel
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;
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引用

Rödelsperger, C., Prabh, N., & Sommer, R. J. (2019). New gene origin and deep taxon phylogenomics: opportunities and challenges. Trends in Genetics, 35(12), 914-922. doi:10.1016/j.tig.2019.08.007.

引用: https://hdl.handle.net/21.11116/0000-0009-4D66-F

要旨

The immense morphological and phenotypic diversity within eukaryotes coincides with large-scale differences in genic repertoires, including the presence of thousands of new genes in every genome. New genes arise through duplication and divergence of existing coding sequences or de novo from noncoding sequences. These processes together cause individual genomes to contain up to one-third of orphan genes without any detectable homology in other lineages. Recently, deep taxon phylogenomics, the genome comparisons of extremely closely related species, provided novel insight into the evolutionary dynamics of such rapidly evolving genes. This review focuses on deep taxon phylogenomics and its importance in studying the evolution of new genes and discusses challenges and opportunities.