Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

New roles for astrocytes in developing synaptic circuits


Barker,  Alison J.
Social Systems and Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;
Departments of Ophthalmology and Physiology; University of California, San Francisco; San Francisco, California USA.;

External Resource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Barker, A. J., & Ullian, E. M. (2008). New roles for astrocytes in developing synaptic circuits. Commun Integr Biol, 1(2), 207-211. doi:10.4161/cib.1.2.7284.

Cite as: http://hdl.handle.net/21.11116/0000-0009-63DC-0
Glial cells comprise 90% of the human brain.1 Glia are divided into two subtypes, the microglia which function largely as scavengers to engulf apoptotic cell debris and the macroglia comprised of oligodendrocytes that myelinate axons, and astrocytes.2 Here we focus on the astrocyte which has many well-defined functions; astrocytes control ion homeostasis, uptake glutamate at the synapse and provide metabolic support for neighboring neurons.1-3 The past several decades have seen an expansion in our understanding of astrocyte roles in the brain, specifically at the synapse where they influence formation and function.3 Here, we review in vitro experiments that led to the identification of astrocyte secreted factors and astrocyte contact effects that influence synapse formation. We then shift to a discussion of in vivo data, where we focus on the developmental role of astrocytes. Recent imaging studies have expanded our understanding of how neurons and astrocytes interact during these initial contacts, when synapses are extensively forming. We highlight recent work from our lab where we demonstrate that astrocyte contact is necessary for the synaptic maturation of developing neurons. Finally, we contrast these developmental interactions with astrocyte organization in the adult brain and discuss what these differences might mean in the context of plasticity.