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Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

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Wotjak,  Carsten T.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Haaker, J., Maren, S., Marta, A., Merz, C. J., Richter, J., Helene, R. S., et al. (2019). Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 107, 329-345. doi:10.1016/j.neubiorev.2019.09.020.


Cite as: https://hdl.handle.net/21.11116/0000-0009-7327-A
Abstract
Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.