Making translation work: Harmonizing cross-species methodology in the 
behavioural neuroscience of Pavlovian fear conditioning

Haaker, Jan; Maren, Stephen; Marta, Andreatta; Merz, Christian J.; Richter, Jan; Helene, Richter S.; Shira, Meir Drexler; Lange, Maren D.; Kay, Jungling; Nees, Frauke; Seidenbecher, Thomas; Fullana, Miquel A.; Wotjak, Carsten T.; Lonsdorf, Tina B.

doi:10.1016/j.neubiorev.2019.09.020

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Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

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Wotjak, Carsten T.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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引用: https://hdl.handle.net/21.11116/0000-0009-7327-A

要旨

Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.