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Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder

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Martins,  Jade
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Czamara,  Darina
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Lange,  Jennifer
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Dethloff,  Frederik
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Binder,  Elisabeth B.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Turck,  Christoph W.
RG Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Max Planck Society;

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Erhardt,  Angelika
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Martins, J., Czamara, D., Lange, J., Dethloff, F., Binder, E. B., Turck, C. W., et al. (2019). Exposure-induced changes of plasma metabolome and gene expression in patients with panic disorder. DEPRESSION AND ANXIETY, 36(12), 1173-1181. doi:10.1002/da.22946.


Cite as: http://hdl.handle.net/21.11116/0000-0009-6555-6
Abstract
Background Anxiety disorders including panic disorder (PD) are the most prevalent psychiatric diseases leading to high disability and burden in the general population. Acute panic attacks are distinctive for PD but also frequent in other anxiety disorders. The neurobiology or specific molecular changes leading to and present during panic attacks are insufficiently known so far. Methods In the present pilot study, we investigated dynamic metabolomic and gene expression changes in peripheral blood of patients with PD (n = 25) during two exposure-induced acute panic attacks. Results The results show that the metabolite glyoxylate was dynamically regulated in peripheral blood. Additionally, glyoxylate levels were associated with basal anxiety levels and showed gender-related differences at baseline. As glyoxylate is part of the degradation circuit of cholecystokinin, this suggests that this neuropeptide might be directly involved in exposure-induced panic attacks. Only gene expression changes of very small magnitude were observed in this experimental setting. Conclusions From this first metabolome and gene expression study in exposure-induced acute panic attacks in PD we conclude that metabolites can potentially serve as dynamic markers for different anxiety states. However, these findings have to be replicated in cohorts with greater sample sizes.