English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The influence of religious activity and polygenic schizophrenia risk on religious delusions in schizophrenia

MPS-Authors
/persons/resource/persons262379

Kalman,  Janos L.
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262641

Comes,  Ashley L.
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons125664

Andlauer,  Till F. M.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Anderson-Schmidt, H., Gade, K., Malzahn, D., Papiol, S., Budde, M., Heilbronner, U., et al. (2019). The influence of religious activity and polygenic schizophrenia risk on religious delusions in schizophrenia. SCHIZOPHRENIA RESEARCH, 210, 255-261. doi:10.1016/j.schres.2018.12.025.


Cite as: https://hdl.handle.net/21.11116/0000-0009-98EF-F
Abstract
Background: Religious delusions are a common symptom in patients experiencing psychosis, with varying prevalence rates of religious delusions across cultures and societies. To enhance our knowledge of this distinct psychotic feature, we investigated the mutually-adjusted association of genetic and environmental factors with occurrence of religious delusions.
Methods: We studied 262 adult German patients with schizophrenia or schizoaffective disorder. Associationwith lifetime occurrence of religious delusions was tested by multiple logistic regression for the following putative predictors: self-reported degree of religious activity, DSM-IV diagnosis, sex, age, education level, marital status, presence of acute delusion at the time of interview and an individual polygenic schizophrenia-risk score (SZPRS, available in 239 subjects).
Results: Of the 262 patients, 101 (39%) had experienced religious delusions. The risk of experiencing religious delusions was significantly increased in patients with strong religious activity compared to patients without religious affiliation (OR = 3.6, p = 0.010). Low or moderate religious activity had no significant effect. The same analysis including the SZ-PRS confirmed the effect of high religious activity on occurrence of religious delusions (OR = 4.1, p = 0.008). Additionally, the risk of experiencing religious delusions increased with higher SZ-PRS (OR 1.4, p= 0.020, using pT= 0.05 for SZ-PRS calculation). None of the other variables were significantly associated with lifetime occurrence of religious delusions.
Conclusions: Our results suggest that strong religious activity and high SZ-PRS are independent risk factors for the occurrence of religious delusions in schizophrenia and schizoaffective disorder. (C) 2018 Published by Elsevier B.V.