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Journal Article

Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

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Ecke,  Mary
Gerisch, Günther / Cell Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Prassler,  Jana
Gerisch, Günther / Cell Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Gerisch,  Günther
Gerisch, Günther / Cell Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Ecke, M., Prassler, J., & Gerisch, G. (2021). Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells, 10(9): 2240. doi:10.3390/cells10092240.


Cite as: https://hdl.handle.net/21.11116/0000-0009-5DEF-3
Abstract
Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.