Ten millennia of hepatitis B virus evolution

Kocher, Arthur; Papac, Luka; Barquera Lozano, Rodrigo José; Key, Felix Michael; Spyrou, Maria A.; Hübler, Ron; Rohrlach, Adam Ben; Aron, Franziska; Stahl, Raphaela; Wissgott, Antje; van Bömmel, Florian; Pfefferkorn, Maria; Mittnik, Alissa; Villalba-Mouco, Vanessa; Neumann, Gunnar; Rivollat, Maïté; Loosdrecht, Marieke Sophia van de; Majander, Kerttu; Tukhbatova, Rezeda I.; Musralina, Lyazzat; Ghalichi, Ayshin; Penske, Sandra Ellen; Sabin, Susanna; Michel, Megan; Gretzinger, Joscha; Nelson, Elizabeth A.; Ferraz da Silva, Tiago; Nägele, Kathrin; Parker, Cody Edward; Keller, Marcel; Guevara, Evelyn; Feldman, Michal; Eisenmann, Stefanie; Skourtanioti, Eirini; Giffin, Karen; Gnecchi Ruscone, Guido Alberto; Friederich, Susanne; Schimmenti, Vittoria; Khartanovich, Valery; Karapetian, Marina K.; Chaplygin, Mikhail S.; Kufterin, Vladimir V.; Khokhlov, Aleksandr A.; Chizhevsky, Andrey A.; Stashenkov, Dmitry A.; Kochkina, Anna F.; Tejedor-Rodríguez, Cristina; de Lagrán, Íñigo García-Martínez; Arcusa-Magallón, Héctor; Garrido-Pena, Rafael; Royo-Guillén, José Ignacio; Novácek, Jan; Rottier, Stéphane; Kacki, Sacha; Saintot, Sylvie; Kaverzneva, Elena; Belinskiy, Andrej B.; Velemínský, Petr; Limburský, Petr; Kostka, Michal; Loe, Louise; Popescu, Elizabeth; Clarke, Rachel; Lyons, Alice; Mortimer, Richard; Sajantila, Antti; de Armas, Yadira Chinique; Godoy, Silvia Teresita Hernandez; Hernández-Zaragoza, Diana I.; Pearson, Jessica; Binder, Didier; Lefranc, Philippe; Kantorovich, Anatoly R.; Maslov, Vladimir E.; Lai, Luca; Zoledziewska, Magdalena; Beckett, Jessica F.; Langová, Michaela; Danielisová, Alžbeta; Ingman, Tara; Atiénzar, Gabriel García; de Ibáñez, Maria Paz Miguel; Romero, Alejandro; Sperduti, Alessandra; Beckett, Sophie; Salter, Susannah J.; Zilivinskaya, Emma D.; Vasilev, Dmitry V.; von Heyking, Kristin; Burger, Richard L.; Salazar, Lucy C.; Amkreutz, Luc; Navruzbekov, Masnav; Rosenstock, Eva; Alonso-Fernández, Carmen; Slavchev, Vladimir; Kalmykov, Alexey A.; Atabiev, Biaslan Ch.; Batieva, Elena; Calmet, Micaela Alvarez; Llamas, Bastien; Schultz, Michael; Krauß, Raiko; Jiménez-Echevarría, Javier; Francken, Michael; Shnaider, Svetlana; de Knijff, Peter; Altena, Eveline; de Vijver, Katrien Van; Fehren-Schmitz, Lars; Tung, Tiffiny A.; Lösch, Sandra; Dobrovolskaya, Maria; Makarov, Nikolaj; Read, Chris; Twest, Melanie Van; Sagona, Claudia; Ramsl, Peter C.; Akar, Murat; Yener, K. Aslihan; Ballestero, Eduardo Carmona; Cucca, Francesco; Mazzarello, Vittorio; Utrilla, Pilar; Rademaker, Kurt; Fernández-Domínguez, Eva; Baird, Douglas; Semal, Patrick; Márquez-Morfín, Lourdes; Roksandic, Mirjana; Steiner, Hubert; Salazar-García, Domingo Carlos; Shishlina, Natalia; Erdal, Yilmaz Selim; Hallgren, Fredrik; Boyadzhiev, Yavor; Boyadzhiev, Kamen; Küßner, Mario; Sayer, Duncan; Onkamo, Päivi; Skeates, Robin; Rojo-Guerra, Manuel; Buzhilova, Alexandra; Khussainova, Elmira; Djansugurova, Leyla B.; Beisenov, Arman Z.; Samashev, Zainolla; Massy, Ken; Mannino, Marcello; Moiseyev, Vyacheslav; Mannermaa, Kristiina; Balanovsky, Oleg; Deguilloux, Marie-France; Reinhold, Sabine; Hansen, Svend; Kitov, Egor P.; Dobeš, Miroslav; Ernée, Michal; Meller, Harald; Alt, Kurt W.; Prüfer, Kay; Warinner, Christina G.; Schiffels, Stephan; Stockhammer, Philipp W.; Bos, Kirsten I.; Posth, Cosimo; Herbig, Alexander; Haak, Wolfgang; Krause, Johannes; Kühnert, Denise

doi:10.1126/science.abi5658

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Ten millennia of hepatitis B virus evolution

MPS-Authors

/persons/resource/persons247389

Kocher, Arthur
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222931

Papac, Luka
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons214002

Barquera Lozano, Rodrigo José
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons134347

Key, Felix Michael
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons189338

Spyrou, Maria A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons127181

Hübler, Ron
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons247243

Rohrlach, Adam Ben
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons239676

Aron, Franziska
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons246189

Stahl, Raphaela
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons59177

Wissgott, Antje
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188732

Mittnik, Alissa
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons231928

Villalba-Mouco, Vanessa
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons239489

Neumann, Gunnar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons247987

Rivollat, Maïté
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221869

Loosdrecht, Marieke Sophia van de
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222873

Majander, Kerttu
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222993

Tukhbatova, Rezeda I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons259907

Musralina, Lyazzat
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons260929

Ghalichi, Ayshin
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons247910

Penske, Sandra Ellen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222907

Sabin, Susanna
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222878

Michel, Megan
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons240852

Gretzinger, Joscha
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222236

Nelson, Elizabeth A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221577

Ferraz da Silva, Tiago
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons207357

Nägele, Kathrin
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons261916

Parker, Cody Edward
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons198464

Keller, Marcel
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons266746

Guevara, Evelyn
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons198467

Feldman, Michal
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons225591

Eisenmann, Stefanie
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons222963

Skourtanioti, Eirini
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221579

Giffin, Karen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons231930

Gnecchi Ruscone, Guido Alberto
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72912

Prüfer, Kay
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221103

Warinner, Christina G.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188297

Schiffels, Stephan
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons207359

Stockhammer, Philipp W.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188392

Bos, Kirsten I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188736

Posth, Cosimo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons179620

Herbig, Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons186115

Haak, Wolfgang
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72801

Krause, Johannes
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221052

Kühnert, Denise
tide, Max Planck Institute for the Science of Human History, Max Planck Society;
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource

Materials and Methods, Supplementary Text, Figs. S1 to S10, Tables S1 to S5, References (59–254)
(Supplementary material)

Data S1 to S4
(Supplementary material)

MDAR Reproducibility Checklist
(Supplementary material)

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Citation

Kocher, A., Papac, L., Barquera Lozano, R. J., Key, F. M., Spyrou, M. A., Hübler, R., et al. (2021). Ten millennia of hepatitis B virus evolution. Science, 374(6564): abi5658, pp. 182-188. doi:10.1126/science.abi5658.

Cite as: https://hdl.handle.net/21.11116/0000-0009-6D08-5

Abstract

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.