The Molecular Architecture of HIV

Briggs, John A. G.; Krausslich, H. G.

doi:10.1016/j.jmb.2011.04.021

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

The Molecular Architecture of HIV

MPS-Authors

Krausslich, H. G.
Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Briggs, J. A. G., & Krausslich, H. G. (2011). The Molecular Architecture of HIV. Journal of Molecular Biology, 410(4), 491-500. doi:10.1016/j.jmb.2011.04.021.

Cite as: https://hdl.handle.net/21.11116/0000-0009-70DC-1

Abstract

Assembly of human immunodeficiency virus type 1 is driven by oligomerization of the Gag polyprotein at the plasma membrane of an infected cell, leading to membrane envelopment and budding of an immature virus particle. Proteolytic cleavage of Gag at five positions subsequently causes a dramatic rearrangement of the interior virion organization to form an infectious particle. Within the mature virus, the genome is encased within a conical capsid core. Here, we describe the molecular architecture of the virus assembly site, the immature virus, the maturation intermediates and the mature virus core and highlight recent advances in our understanding of these processes from electron microscopy and X-ray crystallography studies. (C) 2011 Elsevier Ltd. All rights reserved.