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Automated glycan assembly of peptidoglycan backbone fragments

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Dallabernardina,  Pietro
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

Benazzi,  Valentina
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Löffler,  Felix F.
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Dallabernardina, P., Benazzi, V., Laman, J. D., Seeberger, P. H., & Löffler, F. F. (2021). Automated glycan assembly of peptidoglycan backbone fragments. Organic & Biomolecular Chemistry, 19(45), 9829-9832. doi:10.1039/D1OB01987B.


Cite as: http://hdl.handle.net/21.11116/0000-0009-7A0B-3
Abstract
We report the automated glycan assembly (AGA) of different oligosaccharide fragments of the bacterial peptidoglycan (PGN) backbone. Iterative addition on a solid support of an acetyl glucosamine and a new muramic acid building block is followed by cleavage from the solid support and final deprotection providing 10 oligosaccharides up to six units.