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Journal Article

Defining NASH from a Multi-Omics Systems Biology Perspective

MPS-Authors
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Niu,  Lili
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Vasilopoulou,  Catherine G.
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Meier,  Florian
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons78356

Mann,  Matthias
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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jcm-10-04673.pdf
(Publisher version), 2MB

Supplementary Material (public)

jcm-10-04673-s001.zip
(Supplementary material), 23KB

Citation

Niu, L., Sulek, K., Vasilopoulou, C. G., Santos, A., Wewer Albrechtsen, N. J., Rasmussen, S., et al. (2021). Defining NASH from a Multi-Omics Systems Biology Perspective. Journal of Clinical Medicine, 10(20): 4673. doi:10.3390/jcm10204673.


Cite as: https://hdl.handle.net/21.11116/0000-0009-7B76-9
Abstract
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease affecting up to 6.5% of the general population. There is no simple definition of NASH, and the molecular mechanism underlying disease pathogenesis remains elusive. Studies applying single omics technologies have enabled a better understanding of the molecular profiles associated with steatosis and hepatic inflammation-the commonly accepted histologic features for diagnosing NASH, as well as the discovery of novel candidate biomarkers. Multi-omics analysis holds great potential to uncover new insights into disease mechanism through integrating multiple layers of molecular information. Despite the technical and computational challenges associated with such efforts, a few pioneering studies have successfully applied multi-omics technologies to investigate NASH. Here, we review the most recent technological developments in mass spectrometry (MS)-based proteomics, metabolomics, and lipidomics. We summarize multi-omics studies and emerging omics biomarkers in NASH and highlight the biological insights gained through these integrated analyses.</p>