Enhanced antiviral function of magnesium chloride-modified Heparin on a broad 
spectrum of viruses

Mese, K.; Bunz, O.; Volkwein, W.; Vemulapalli, S. P.; Zhang, W. L; Schellhorn, S.; Heenemann, K.; Rueckner, A.; Sing, A.; Vahlenkamp, T.W.; Severing, A. L.; Gao, J.; Aydin, M.; Jung, D.; Bachmann, H. S.; Zanker, K. S.; Busch, U.; Baiker, A.; Griesinger, C.; Griesinger, C.; Ehrhardt, A.

doi:10.3390/ijms221810075

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Enhanced antiviral function of magnesium chloride-modified Heparin on a broad spectrum of viruses

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Vemulapalli, S. P.
Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Griesinger, C.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Mese, K., Bunz, O., Volkwein, W., Vemulapalli, S. P., Zhang, W. L., Schellhorn, S., et al. (2021). Enhanced antiviral function of magnesium chloride-modified Heparin on a broad spectrum of viruses. Journal of Molecular Sciences, 22(18): 10075. doi:10.3390/ijms221810075.

Cite as: https://hdl.handle.net/21.11116/0000-0009-8337-5

Abstract

Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.