Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Molecular and cellular mechanisms of lamina-specific axon targeting

There are no MPG-Authors in the publication available
External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Huberman, A. D., Clandinin, T. R., & Baier, H. (2010). Molecular and cellular mechanisms of lamina-specific axon targeting. Cold Spring Harbor Perspectives in Biology, 2(3): a001743. doi:10.1101/cshperspect.a001743.

Cite as: https://hdl.handle.net/21.11116/0000-0009-873A-E
The specificity of synaptic connections is directly related to the functional integrity of neural circuits. Long-range axon guidance and topographic mapping mechanisms bring axons into spatial proximity of target cells and thus limit the number of potential synaptic partners. Synaptic specificity is then achieved by extracellular short-range guidance cues and cell-surface recognition cues. Neural activity may enhance the precision and strength of specific circuit connections. Here, we focus on one of the final steps of synaptic matchmaking: the targeting of synaptic layers and the mutual recognition of axons and dendrites within these layers.