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Relationship between regional white matter hyperintensities and alpha oscillations in older adults

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Kumral,  Deniz
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, Albert Ludwigs University Freiburg, Germany;
Department of Clinical Psychology and Psychotherapy, Albert Ludwigs University Freiburg, Germany;

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Cesnaite,  Elena
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Beyer,  Frauke
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Hofmann,  Simon       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Witte,  A. Veronica
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Nikulin,  Vadim V.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia;

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Citation

Kumral, D., Cesnaite, E., Beyer, F., Hofmann, S., Hensch, T., Sander, C., et al. (2022). Relationship between regional white matter hyperintensities and alpha oscillations in older adults. Neurobiology of Aging, 112, 1-11. doi:10.1016/j.neurobiolaging.2021.10.006.


Cite as: https://hdl.handle.net/21.11116/0000-0009-91B5-6
Abstract
Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources.