Wnt/beta-catenin signaling acts cell-autonomously to promote cardiomyocyte 
regeneration in the zebrafish heart

Bertozzi, Alberto; Wu, Chi-Chung; Hans, Stefan; Brand, Michael; Weidinger, Gilbert

doi:10.1016/j.ydbio.2021.11.001

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Wnt/beta-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart

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Wu, Chi-Chung
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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引用

Bertozzi, A., Wu, C.-C., Hans, S., Brand, M., & Weidinger, G. (2022). Wnt/beta-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. DEVELOPMENTAL BIOLOGY, 481, 226-237. doi:10.1016/j.ydbio.2021.11.001.

引用: https://hdl.handle.net/21.11116/0000-0009-9C31-0

要旨

Zebrafish can achieve scar-free healing of heart injuries, and robustly replace all cardiomyocytes lost to injury via dedifferentiation and proliferation of mature cardiomyocytes. Previous studies suggested that Wnt/beta-catenin signaling is active in the injured zebrafish heart, where it induces fibrosis and prevents cardiomyocyte cell cycling. Here, via targeting the destruction complex of the Wnt/beta-catenin pathway with pharmacological and genetic tools, we demonstrate that Wnt/beta-catenin activity is required for cardiomyocyte proliferation and dedifferentiation, as well as for maturation of the scar during regeneration. Using cardiomyocyte-specific conditional inhibition of the pathway, we show that Wnt/beta-catenin signaling acts cell-autonomously to promote cardiomyocyte proliferation. Our results stand in contrast to previous reports and rather support a model in which Wnt/beta-catenin signaling plays a positive role during heart regeneration in zebrafish.