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Journal Article

Bottom-up reconstitution of focal adhesion complexes


Schumacher,  Stephanie
Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Schumacher, S., Vazquez Nunez, R., Biertümpfel, C., & Mizuno, N. (2021). Bottom-up reconstitution of focal adhesion complexes. The FEBS Journal. doi:10.1111/febs.16023.

Cite as: https://hdl.handle.net/21.11116/0000-000A-11B5-6
Focal adhesions (FA) are large macromolecular assemblies relevant for various cellular and pathological events such as migration, polarization, and metastatic cancer formation. At FA sites at the migrating periphery of a cell, hundreds of players gather and form a network to respond to extra cellular stimuli transmitted by the integrin receptor, the most upstream component within a cell, initiating the FA signaling pathway. Numerous cellular experiments have been performed to understand the FA architecture and functions; however, their intricate network formation hampers unraveling the precise molecular actions of individual players. Here, in vitro bottom-up reconstitution presents an advantageous approach for elucidating the FA machinery and the hierarchical crosstalk of involved cellular players.