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Journal Article

Bottom-up reconstitution of focal adhesion complexes

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Schumacher,  Stephanie
Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Schumacher, S., Vazquez Nunez, R., Biertümpfel, C., & Mizuno, N. (2021). Bottom-up reconstitution of focal adhesion complexes. The FEBS Journal. doi:10.1111/febs.16023.


Cite as: http://hdl.handle.net/21.11116/0000-000A-11B5-6
Abstract
Focal adhesions (FA) are large macromolecular assemblies relevant for various cellular and pathological events such as migration, polarization, and metastatic cancer formation. At FA sites at the migrating periphery of a cell, hundreds of players gather and form a network to respond to extra cellular stimuli transmitted by the integrin receptor, the most upstream component within a cell, initiating the FA signaling pathway. Numerous cellular experiments have been performed to understand the FA architecture and functions; however, their intricate network formation hampers unraveling the precise molecular actions of individual players. Here, in vitro bottom-up reconstitution presents an advantageous approach for elucidating the FA machinery and the hierarchical crosstalk of involved cellular players.