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Journal Article

Single-cell delineation of lineage and genetic identity in the mouse brain

MPS-Authors
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Bandler,  Rachel C.
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

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Vitali,  Ilaria
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons268252

Ho,  May C.
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons268254

Dvoretskova,  Elena
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons268257

Ibarra Molinas,  Josue S.
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

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Mayer,  Christian
Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society;

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Fulltext (public)

s41586-021-04237-0.pdf
(Publisher version), 72MB

Supplementary Material (public)
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Citation

Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Ibarra Molinas, J. S., et al. (2022). Single-cell delineation of lineage and genetic identity in the mouse brain. Nature, 601(7893), 404-409. doi:10.1038/s41586-021-04237-0.


Cite as: http://hdl.handle.net/21.11116/0000-0009-AF10-0
Abstract
During neurogenesis, mitotic progenitor cells lining the ventricles ofthe embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia(1,2). The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.