The protein import machinery of mitochondria - A regulatory hub in metabolism, 
stress, and disease

Harbauer, Angelika B.; Zahedi, R. P.; Sickmann, A.; Pfanner, N.; Meisinger, C.

doi:10.1016/j.cmet.2014.01.010

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

The protein import machinery of mitochondria - A regulatory hub in metabolism, stress, and disease

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Harbauer, A. B., Zahedi, R. P., Sickmann, A., Pfanner, N., & Meisinger, C. (2014). The protein import machinery of mitochondria - A regulatory hub in metabolism, stress, and disease. Cell Metabolism, 19(3), 357-372. doi:10.1016/j.cmet.2014.01.010.

Cite as: https://hdl.handle.net/21.11116/0000-0009-B16A-8

Abstract

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more than 1,000 different proteins from the cytosol. It had been assumed that the protein import machinery is constitutively active and not subject to detailed regulation. However, recent studies indicate that mitochondrial protein import is regulated at multiple levels connected to cellular metabolism, signaling, stress, and pathogenesis of diseases. Here, we discuss the molecular mechanisms of import regulation and their implications for mitochondrial homeostasis. The protein import activity can function as a sensor of mitochondrial fitness and provides a direct means of regulating biogenesis, composition, and turnover of the organelle.