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Journal Article

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans

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Pääbo,  Svante       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Zeberg,  Hugo       
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Coppo_A-substitution_SciAdv_2022.pdf
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Citation

Coppo, L., Mishra, P., Siefert, N., Holmgren, A., Pääbo, S., & Zeberg, H. (2022). A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans. Science Advances, 8(1): eabm1148. doi:10.1126/sciadv.abm1148.


Cite as: https://hdl.handle.net/21.11116/0000-0009-B92A-8
Abstract
Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whereas the activity and stability are unaffected by the amino acid substitution, the ancestral enzyme produces more reactive oxygen species and increases cellular levels of transcripts encoding cytokines. We furthermore show that the ancestral enzyme has been reintroduced into the modern human gene pool by gene flow from Neanderthals and is associated with multiple traits in present-day people, including increased susceptibility for inflammatory-associated disorders and vascular disease.