Signaling by Eph receptors and their ephrin ligands

Brückner, K.; Klein, Rüdiger

doi:10.1016/s0959-4388(98)80064-0

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Signaling by Eph receptors and their ephrin ligands

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Brückner, K., & Klein, R. (1998). Signaling by Eph receptors and their ephrin ligands. Current Opinion in Neurobiology, 8(3), 375-382. doi:10.1016/s0959-4388(98)80064-0.

Cite as: https://hdl.handle.net/21.11116/0000-0009-BE2B-2

Abstract

What are the mechanisms by which Eph receptor tyrosine kinases guide axons and migrating cells? Recent results show that Eph receptors bind some of the well-known effector molecules that are implicated in the organization of the actin cytoskeleton; moreover, biochemical and genetic evidence suggests a signaling role for transmembrane ephrin ligands in axon pathfinding.