Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in 
silico studies

Waclawiková, Barbora; Codutti, Agnese; Alim, Karen; El Aidy, Sahar

doi:10.1080/19490976.2021.1997296

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Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies

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Codutti, Agnese
Max Planck Research Group Biological Physics and Morphogenesis, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Alim, Karen
Max Planck Research Group Biological Physics and Morphogenesis, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Citation

Waclawiková, B., Codutti, A., Alim, K., & El Aidy, S. (2022). Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies. Gut Microbes, 14(1): e1997296. doi:10.1080/19490976.2021.1997296.

Cite as: https://hdl.handle.net/21.11116/0000-0009-C4B6-C

Abstract

The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities have
a significant regulatory role in the intestinal physiology, such as gut motility. Microbial effect on gut
motility is often evoked by bioactive molecules from various sources, including microbial break
down of carbohydrates, fibers or proteins. In turn, gut motility regulates the colonization within the
microbial ecosystem. However, the underlying mechanisms of such regulation remain obscure.
Deciphering the inter-regulatory mechanisms of the microbiota and bowel function is crucial for
the prevention and treatment of gut dysmotility, a comorbidity associated with many diseases. In
this review, we present an overview of the current knowledge on the impact of gut microbiota and
its products on bowel motility. We discuss the currently available techniques employed to assess
the changes in the intestinal motility. Further, we highlight the open challenges, and incorporate
biophysical elements of microbes-motility interplay, in an attempt to lay the foundation for
describing long-term impacts of microbial metabolite-induced changes in gut motility.