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A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss

MPS-Authors
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Lewis,  Carolin Annette
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany;

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Mueller,  Karsten
Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zsido,  Rachel
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Reinelt,  Janis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Okon-Singer,  Hadas
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, University of Haifa, Isreal;
Integrated Brain and Behavior Research Center (IBBR), University of Haifa, Isreal;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Sacher,  Julia
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Lewis_2021.pdf
(Publisher version), 329KB

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Citation

Lewis, C. A., Mueller, K., Zsido, R., Reinelt, J., Regenthal, R., Okon-Singer, H., et al. (2021). A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss. Journal of Psychiatry & Neuroscience, 46, E319-E327. doi:10.1503/jpn.200121.


Cite as: http://hdl.handle.net/21.11116/0000-0009-C8A9-7
Abstract
Background: Selective serotonin reuptake inhibitors (SSRIs) show acute effects on the neural processes associated with negative affective bias in healthy people and people with depression. However, whether and how SSRIs also affect reward and punishment processing on a similarly rapid time scale remains unclear. Methods: We investigated the effects of an acute and clinically relevant dose (20 mg) of the SSRI escitalopram on brain response during reward and punishment processing in 19 healthy participants. In a doubleblind, placebo-controlled study using functional MRI, participants performed a well-established monetary reward task at 3 time points: at baseline; after receiving placebo or escitalopram; and after receiving placebo or escitalopram following an 8-week washout period. Results: Acute escitalopram administration reduced blood-oxygen-level-dependent (BOLD) response during punishment feedback in the right thalamus (family-wise error corrected [FWE] p = 0.013 at peak level) and the right caudate head (pFWE = 0.011 at peak level) compared to placebo. We did not detect any significant BOLD changes during reward feedback. Limitations: We included only healthy participants, so interpretation of findings are limited to the healthy human brain and require future testing in patient populations. The paradigm we used was based on monetary stimuli, and results may not be generalizable to other forms of reward. Conclusion: Our findings extend theories of rapid SSRI action on the neural processing of rewarding and aversive stimuli and suggest a specific and acute effect of escitalopram in the punishment neurocircuitry.