The interplay between dysregulated ion transport and mitochondrial architecture 
as a dangerous liaison in cancer

Pedersen, S. F.; Flinck, M.; Pardo, Luis A.

doi:10.3390/ijms22105209

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The interplay between dysregulated ion transport and mitochondrial architecture as a dangerous liaison in cancer

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Pardo, Luis A.
Oncophysiology, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Pedersen, S. F., Flinck, M., & Pardo, L. A. (2021). The interplay between dysregulated ion transport and mitochondrial architecture as a dangerous liaison in cancer. International Journal of Molecular Sciences, 22(10): 5209. doi:10.3390/ijms22105209.

Cite as: https://hdl.handle.net/21.11116/0000-000A-20A1-B

Abstract

Transport of ions and nutrients is a core mitochondrial function, without which there would be no mitochondrial metabolism and ATP production. Both ion homeostasis and mitochondrial phenotype undergo pervasive changes during cancer development, and both play key roles in driving the malignancy. However, the link between these events has been largely ignored. This review comprehensively summarizes and critically discusses the role of the reciprocal relationship between ion transport and mitochondria in crucial cellular functions, including metabolism, signaling, and cell fate decisions. We focus on Ca2+, H+, and K+, which play essential and highly interconnected roles in mitochondrial function and are profoundly dysregulated in cancer. We describe the transport and roles of these ions in normal mitochondria, summarize the changes occurring during cancer development, and discuss how they might impact tumorigenesis. View Full-Text
Keywords: mitochondrial fission; mitochondrial fusion; calcium; pH; potassium; membrane potential; metabolism; apoptosis; cell cycle; metastasis