English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Nonlinear microscopy using impulsive stimulated Brillouin scattering for high-speed elastography

MPS-Authors
/persons/resource/persons241284

Guck,  Jochen
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Guck Division, Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Opt Express 2022 Krug.pdf
(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Krug, B., Koukourakis, N., Guck, J., & Czarske, J. (2022). Nonlinear microscopy using impulsive stimulated Brillouin scattering for high-speed elastography. Optics Express, 30(4), 4748-4758. doi:10.1364/OE.449980.


Cite as: https://hdl.handle.net/21.11116/0000-0009-F828-3
Abstract
The impulsive stimulated Brillouin microscopy promises fast, non-contact measurements of the elastic properties of biological samples. The used pump-probe approach employs an ultra-short pulse laser and a cw laser to generate Brillouin signals. Modeling of the microscopy technique has already been carried out partially, but not for biomedical applications. The nonlinear relationship between pulse energy and Brillouin signal amplitude is proven with both simulations and experiments. Tayloring of the excitation parameters on the biologically relevant polyacrylamide hydrogels outline sub-ms temporal resolutions at a relative precision of <1%. Brillouin microscopy using the impulsive stimulated scattering therefore exhibits high potential for the measurements of viscoelastic properties of cells and tissues.