Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. 
(Agaricales)

Sarawi, Sepas; Shi, Yan-Ni; Lotz-Winter, Hermine; Reschke, Kai; Bode, Helge B.; Piepenbring, Meike

doi:10.1016/j.phytochem.2021.113069

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales)

MPS-Authors

/persons/resource/persons269155

Shi, Yan-Ni
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

/persons/resource/persons256033

Bode, Helge B.
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

External Resource

https://doi.org/10.1016/j.phytochem.2021.113069
(出版社版)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Sarawi, S., Shi, Y.-N., Lotz-Winter, H., Reschke, K., Bode, H. B., & Piepenbring, M. (2022). Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales). Phytochemistry, 195:. doi:10.1016/j.phytochem.2021.113069.

引用: https://hdl.handle.net/21.11116/0000-000A-0552-4

要旨

About 95% of fatal mushroom poisonings worldwide are caused by amatoxins and phallotoxins mostly produced by species of Amanita, Galerina, and Lepiota. The genus Lepiota is supposed to include a high number of species producing amatoxins. In this study, we investigated 16 species of Lepiota based on 48 recently collected specimens for the presence of amatoxins by liquid chromatography coupled to a diode-array detector and mass spectrometry (UHPLC-QTOF-MS/MS). By comparing the retention times, UV absorptions, and diagnostic MS fragment ions with data obtained from the benchmark species Amanita phalloides, we detected alpha-amanitin and gamma-amanitin in Lepiota subincarnata, alpha-amanitin and amaninamide in Lepiota brunneoincarnata, and beta-amanitin and alpha-amanitin in Lepiota elaiophylla. Phallotoxins have not been detected any of these species. Two possibly undescribed amatoxin derivatives were found in Lepiota boudieri and L. elaiophylla, as well as one further nonamatoxin compound in one specimen of L. cf. boudieri. These compounds might be used to differentiate L. elaiophylla from L. xanthophylla and species within the L. boudieri species complex. No amatoxins were detected in L. aspera, L. castanea, L. clypeolaria, L. cristata, L. erminea, L. felina, L. fuscovinacea, L. lilacea, L. magnispora, L. oreadiformis, L. pseudolilacea, L. sp. (SeSa 5), and L. subalba. By combining the occurrence data of amatoxins with a phylogenetic analysis, a monophyletic group of amatoxin containing species of Lepiota is evident. These chemotaxonomic results highlight the relevance of systematic relationships for the occurrence of amatoxins and expand our knowledge about the toxicity of species of Lepiota.