Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with 
Terminal Reductase Domains

Tietze, Andreas; Shi, Yan-Ni; Kronenwerth, Max; Bode, Helge B.

doi:10.1002/cbic.202000176

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Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

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Shi, Yan-Ni
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Bode, Helge B.
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;
Goethe-Universität Frankfurt am Main, External Organizations;

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引用

Tietze, A., Shi, Y.-N., Kronenwerth, M., & Bode, H. B. (2020). Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains. CHEMBIOCHEM, 21(19), 2750-2754. doi:10.1002/cbic.202000176.

引用: https://hdl.handle.net/21.11116/0000-000A-0510-E

要旨

Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2-electron reduction of the enzyme-bound thioester releasing the generated peptides as C-terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde-generating minimal NRPS termed ATRed in entomopathogenicXenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones.