Synthesis and SAR of the antistaphylococcal natural product nematophin from 
Xenorhabdus nematophila

Wesche, Frank; Adihou, Helene; Wichelhaus, Thomas A.; Bode, Helge B.

doi:10.3762/bjoc.15.47

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Wesche, F., Adihou, H., Wichelhaus, T. A., & Bode, H. B. (2019). Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 15, 535-541. doi:10.3762/bjoc.15.47.

Cite as: https://hdl.handle.net/21.11116/0000-000A-05DA-B

Abstract

The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure-activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.