Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous 
Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli

Zhao, Lei; Cai, Xiaofeng; Kaiser, Marcel; Bode, Helge B.

doi:10.1021/acs.jnatprod.8b00425

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Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli

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Zhao, L., Cai, X., Kaiser, M., & Bode, H. B. (2018). Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli. JOURNAL OF NATURAL PRODUCTS, 81(10), 2292-2295. doi:10.1021/acs.jnatprod.8b00425.

Cite as: https://hdl.handle.net/21.11116/0000-000A-05DE-7

Abstract

Seven new methionine-containing rhabdopeptide/xenortide-like peptides (1-7) were identified from Escherichia coli expressing the rhabdopeptide/xenortide-like peptide biosynthetic gene cluster kj12ABC from Xenorhabdus KJ12.1. Their structures were elucidated by detailed HPLC-HR-MS/MS analysis and confirmed by chemical synthesis. Bioactivity tests of these first rhabdopeptide/xenortide-like peptide derivatives (2-7) showing methionine building blocks compared to the usually found derivatives containing exclusively hydrophobic amino acids such as valine, leucine, or phenylalanine revealed good activities of 2-7 against protozoan parasites and no cytotoxicity against mammalian L6 cells.