Simple "On-Demand" Production of Bioactive Natural Products

Bode, Edna; Brachmann, Alexander O.; Kegler, Carsten; Simsek, Rukayye; Dauth, Christina; Zhou, Qiuqin; Kaiser, Marcel; Klemmt, Petra; Bode, Helge B.

doi:10.1002/cbic.201500094

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Simple "On-Demand" Production of Bioactive Natural Products

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Bode, E., Brachmann, A. O., Kegler, C., Simsek, R., Dauth, C., Zhou, Q., et al. (2015). Simple "On-Demand" Production of Bioactive Natural Products. CHEMBIOCHEM, 16(7), 1115-1119. doi:10.1002/cbic.201500094.

Cite as: https://hdl.handle.net/21.11116/0000-000A-04FA-8

Abstract

Exchange of the native promoter to the arabinose-inducible promoter P-BAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the on-demand production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel mevalagmapeptides and the highly toxic xenorhabdins were identified by this approach.