A multifunctional enzyme is involved in bacterial ether lipid biosynthesis

Lorenzen, Wolfram; Ahrendt, Tilman; Bozhueyuek, Kenan A. J.; Bode, Helge B.

doi:10.1038/nchembio.1526

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A multifunctional enzyme is involved in bacterial ether lipid biosynthesis

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Lorenzen, W., Ahrendt, T., Bozhueyuek, K. A. J., & Bode, H. B. (2014). A multifunctional enzyme is involved in bacterial ether lipid biosynthesis. NATURE CHEMICAL BIOLOGY, 10(6), 425-427. doi:10.1038/nchembio.1526.

Cite as: https://hdl.handle.net/21.11116/0000-000A-0452-5

Abstract

Fatty acid-derived ether lipids are present not only in most vertebrates but also in some bacteria. Here we describe what is to our knowledge the first gene cluster involved in the biosynthesis of such lipids in myxobacteria that encodes the multifunctional enzyme ElbD, which shows similarity to polyketide synthases. Initial characterization of elbD mutants in Myxococcus xanthus and Stigmatella aurantiaca showed the importance of these ether lipids for fruiting body formation and sporulation.