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Journal Article

Initiation of the flexirubin biosynthesis in Chitinophaga pinensis

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Schoener, T. A., Fuchs, S. W., Schoenau, C., & Bode, H. B. (2014). Initiation of the flexirubin biosynthesis in Chitinophaga pinensis. MICROBIAL BIOTECHNOLOGY, 7(3), 232-241. doi:10.1111/1751-7915.12110.

Cite as: https://hdl.handle.net/21.11116/0000-000A-04C6-2
Bacteria from the Bacteroidetes phylum are known producers of the chemotaxonomic relevant flexirubins. These orange pigments comprise a non-isoprenoid aryl-polyene carboxylic acid esterified with a dialkylresorcinol. Herein, we report a gene cluster from Chitinophaga pinensis encoding the biosynthesis of the polyene moiety and the biochemical characterization of a tyrosine ammonia-lyase and a 4-coumarate-CoA ligase responsible for the initiation of the polyene biosynthesis. Additionally, the flexirubin of C.pinensis was characterized by a combination of feeding experiments, high-performance liquid chromatography tandem mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry.