Antiparasitic Chaiyaphumines from Entomopathogenic Xenorhabdus sp PB61.4

Grundmann, Florian; Kaiser, Marcel; Schiell, Matthias; Batzer, Andreas; Kurz, Michael; Thanwisai, Aunchalee; Chantratita, Narisara; Bode, Helge B.

doi:10.1021/np4007525

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Antiparasitic Chaiyaphumines from Entomopathogenic Xenorhabdus sp PB61.4

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Grundmann, F., Kaiser, M., Schiell, M., Batzer, A., Kurz, M., Thanwisai, A., et al. (2014). Antiparasitic Chaiyaphumines from Entomopathogenic Xenorhabdus sp PB61.4. JOURNAL OF NATURAL PRODUCTS, 77(4), 779-783. doi:10.1021/np4007525.

Cite as: https://hdl.handle.net/21.11116/0000-000A-04BA-0

Abstract

A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfey's analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 mu M), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.