Identification and Biosynthesis of a Novel 
Xanthomonadin-Dialkylresorcinol-Hybrid from Azoarcus sp BH72

Schoener, Tim A.; Fuchs, Sebastian W.; Reinhold-Hurek, Barbara; Bode, Helge B.

doi:10.1371/journal.pone.0090922

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Identification and Biosynthesis of a Novel Xanthomonadin-Dialkylresorcinol-Hybrid from Azoarcus sp BH72

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Schoener, T. A., Fuchs, S. W., Reinhold-Hurek, B., & Bode, H. B. (2014). Identification and Biosynthesis of a Novel Xanthomonadin-Dialkylresorcinol-Hybrid from Azoarcus sp BH72. PLOS ONE, 9(3): e90922. doi:10.1371/journal.pone.0090922.

Cite as: https://hdl.handle.net/21.11116/0000-000A-04D0-6

Abstract

A novel xanthomonadin-dialkylresorcinol hybrid named arcuflavin was identified in Azoarcus sp. BH72 by a combination of feeding experiments, HPLC-MS and MALDI-MS and gene clusters encoding the biosynthesis of this non-isoprenoid aryl-polyene containing pigment are reported. A chorismate-utilizing enzyme from the XanB2-type producing 3-and 4-hydroxybenzoic acid and an AMP-ligase encoded by these gene clusters were characterized, that might perform the first two steps of the polyene biosynthesis. Furthermore, a detailed analysis of the already known or novel biosynthesis gene clusters involved in the biosynthesis of polyene containing pigments like arcuflavin, flexirubin and xanthomonadin revealed the presence of similar gene clusters in a wide range of bacterial taxa, suggesting that polyene and polyene-dialkylresorcinol pigments are more widespread than previously realized.